It eliminated my adult acne that appeared when I was 34-35. Anyway, just wanted to share an unbiased opinion here from someone who has had their life changed significantly from this simple vitamin regimen. And the fact that acne-prone skin produces more sebum is already explained with genetic sensitivity to androgen hormones. This agrees with the hormonal nature of acne, but not with Dr. Leung’s theory. While you may see companies marketing vitamin B5 to acne sufferers, your time and money is better spent on reliable acne treatments. It changed my life. True enough. Like most ingredients in the realm of skincare, the correlation between vitamin B5 and acne, and whether or not the former is an effective treatment for the I’ve never experienced it before, and my hair started to recede (I’m a 20 year old male). Keep in mind that placebo tends to work (about 30%) in clearing acne. There are plenty of cell culture studies that show when you expose sebocytes (sebum producing cells) to androgen hormones they produce more sebum. Since vitamin B5 is a water-soluble vitamin, it can be safely taken in the high doses needed for treating acne. It’s possible that B5 affects acne through some mechanism we haven’t yet discovered. As I mentioned in the previous comment he has never established that B5 deficiency exists and that it indeed does limit metabolism of fatty acids, which then leads to excessive sebum production. Megadose of B5/Pantothenic Acid worked for me, hopefully this will help someone. So the placebo is very strong in acne. Will Pantethine be better or worse and why? He doesn’t. But that may be nonsense, I’m not a scientist. There are currently no formal recommendations about what dosage of vitamin B5 you should take to treat acne. But it was done by Neutraceuticals Medical Research, a company that conducts outsources medical research for natural health companies. Well it has for me anyway. I have a daughter now. This sounds like a claim that’s easy to test. My argument would stand perfectly well even without it. Please don’t assume vitamins are automatically safe. And Zinc is very well known to be effective for acne. If anyone can help please do. The only thing I regret is not knowing about it when I was a teenager. I guess everything is possible. I recently read a systematic review of studies of oral antibiotics on acne, and the review concluded that about 60% of the observed benefits were due to placebo. We have no evidence supporting the hypothesis, but many companies (Vilantae is perhaps the most well known) market B5 to acne sufferers. As for Dr. Leung’s hypothesis, I’m no medical researcher and I haven’t looked at all other factors so I can’t tell how probable it is. And they are right. But I stopped taking B5 because I have very very very thick hair and I noticed my hair becoming extremely thin. Milk thistle is an antioxidant that promotes healthy liver function, and I have even read about it on your site. Certainly such low doses of B5 are safe, so it’s worth a try. I tried SkinB5 for a while and followed their regime. Copyright © 1996 - 2020 Daniel W. Kern. The theory makes superficial sense, but doesn’t agree with lot of the research published in the past 15 years, such as reduction in sebum production with low glycemic index diets or green tea creams. While what you say could be applicable to drug companies, I don’t think the same could be said of dermatologists and doctors. this stuff has ruined my life aswell as many others! And that leads to me conclude the study is scientifically worthless but pure gold in marketing terms. Ha! It is no better than the commercials on TV selling products that don’t work. So what did I do? By speeding up fat metabolism, acne is therefore reduced from less oil on the facial skin!!! Let me explain: 1. Because of this we need to conduct blinded and placebo-controlled trials. Of course, you can continue arguing about why didn’t he provide proof for his trial, etc, etc, but again, something not published does not mean it is wrong. All the evidence you are giving to refute his study is about how X and Y INCREASES sebum. This makes it scientifically more or less worthless – but great for marketing purposes. I just cannot believe that medical science cannot cure acne. Several people have also experienced hair loss from megadoses of B5: Vitamin B5 Hair Loss (acne.org forums). My hunch is that acne is not one disease by a variety of diseases, caused by a variety of factors. In skin, T is converted to DHT by the enzyme 5a-R, which acts directly on hair follicles and the sebaceous glands. I think a lot of people don’t 1) take high enough of a dose for it to work 2) wait long enough for it to work. The other issue is that CoA is formed due to B5 and CYSTEINE. N-acetylcysteine has been shown to be quite effective against acne. Are you out of your mind? However, I became heavily skeptical when Dr. Leung mentioned a study he performed on this topic using 100 Chinese patients between the ages of 10-30.2 First, there was no control group in the study. He refers to no studies that show that restricting B5 intake increases sebum production – or vice versa. But what you are really doing is special pleading away contradicting evidence. Not that long ago a meta-analysis of acupuncture studies showed that 100% of the studies coming from China showed positive results. Alt-med people commonly criticize drug companies for doing that. Instead of taking 5 500mg every 2 hours, I’m going to take 4 500mg every 3.5 hours. Feel free to explore . Again I have to state that I would be much more willing to cut him some slack had he provided even some preliminary evidence to back up his theory, see the paper about lipid peroxidation in acne for an example of what I mean. I would however like to come off B5, but feel I have no alternative but to carry on. It’s possible another mechanism exists, but until evidence for it is provided, we have no reason to believe it does. Nothing cured it. Well, I’m 42 and have been in this acne struggle for 15 years and I’m over it. Lack of scientific evidence hasn’t deterred acne patients from experimenting with megadoses of pantothenic acid. Compare Dr. Leung’s paper to this another hypothesis paper about acne: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012032/. If the dose goes too low, the lesions come right back. Appreciate your opinion. The most frequent dermatologic manifestations of androgen excess are hirsutism, acne, and androgenic alopecia. I have seen drastic improvement the last few weeks since I begun taking these supplements. I took massive amounts of B5 and it did wonders for my skin!!! Now using Panthethine to try and find a long term effect but again it works for a limited time. That’s one reason testimonials are so unreliable. It’s also expensive, it feels like a tax on my skin to pay approx £28 every 6 weeks. I read to take the B5 with N-acetylcysteine on multiple websites including those of a pharmacist and other medical professionals. I don’t know why it works, but it does. One of the things that irks me the most of his paper is that he never provided any supporting preliminary data. Hopefully they may have done in another 15 years time. I’m not saying this is necessarily how it happened, but to me it’s a far more plausible explanation than there being some breakthrough mechanism that only Dr. Leung has discovered and yet remains ignored by all the other dermatological scientists in the world. That’s argument from authority. Regardless, it’s a ridiculously shaky ground to build a scientific hypothesis on. I also didn’t say his hypothesis is wrong because of conflict of interest. The very first line “Acne vulgarsis is a common disease of the skin”, already implies that it is a disease. And it happens almost immediately! We will explain the role of Vitamin B5 in the metabolism of fats and oils, and how increasing the metabolism of oils will reduce oil accumulation in the skin, and thereby reduce or eliminate acne. It’s so cheap that I’m surprised there have been any official clinical trials of it. Quite hard to know what to make of stories like yours. Second, the study ran only for 30 days. The only time I ever have a flare up is if I skip a dose (ie, falling asleep before taking it, running out of pills, laziness). Just as cancer is not one disease, but can be classified into 9 different types; It could be likely that acne could be something similar, and these diseases manifests themselves as skin acne. There is no evidence that megadosing on vitamin B5 will help clear acne. Furthermore, he has never shown that B5 is a limiting factor here. I doubt you need to go much higher than 1500 B5 and 1200 mg N acetyl cysteine though, but prehaps it depends on the person.. I’m willing to try anything at this point! If that’s the case, then why sex hormones levels are elevated in acne patients? We can explain this through the effect insulin has on the skin, but not though CoA. But the patent would be proof of “I was first”. Since writing this post a new study has come out that showed B5 supplementation improved the skin barrier function. If these fats are not metabolized and dealt with, they can oxidize in bad ways. Lot of this research is funded by the government and thus independent of what drug companies think. Aside from Dr. Leung’s research, I could find just one study looking at the effect of B5 on acne. The author of the paper graduated from the University of Hong Kong one of the most competitive, finest institutions in Asia (as you may or may not know, many of these graduates go on to study in top institutions in the U.S – Harvard, MIT, Caltech, etc), and in my opinion, the author can be given even a little benefit of the doubt. How good it was scientifically, or whether it even happened. It works! And because it’s needed in so many places Dr. Leung says deficiencies are likely, something mainstream medical science disagrees with. Thanks for writing the article. CoA is required in both fat metabolism, production of hormones and countless other processes in the body. If you have read the paper more carefully, I think you dont understand what he’s getting at (I think you must see the forest for the trees, instead of nitpicking on these small details). This post turned out a bit longer than I expected. The mechanism proposed above may be the reason why two groups of adolescent boys–both with a normal blood level of androgen–may exhibit differences in the incidence of acne. Acne is a common side-effect of testosterone medications, and abuse of anabolic steroids by bodybuilders often also causes acne. What they are doing is very typical in the alt-med/natural health world. I’ve had skin problems into adulthood, was even on antibiotic therapy for too long until I discovered that extra vitamin A actually helped me as much. So perhaps it affects your gut health and that way can worsen your acne. It doesn’t seem to be published anywhere. My personal opinion is that for most people b5 plus n acetyl cysteine will work. There is a known mechanism that explains increased sebum production in acne. No way to know whether it was just a temporary effect, etc. This was two years ago. The group with acne is the one that has not enough of pantothenic acid in the body, whereas in the other group, pantothenic acid levels are not deficient. There probably is a subset of conditions that B5 works on. It’s a shame more people don’t know about it and are suffering with acne! But the fact is that almost everything that he suggests goes against the vast majority of research on acne. Generally, if I miss 1 dose of 5 pills, I’ll get 1-2 cysts within 24 hours. I have looked into results of people using B5 as tool to reduce acne, with dosage ranging between as little as 1,000-2,000mg per day up to crazy megadoses of 5-10g. My son had horrible acne and a friend of mine told me about Vitamin B5. So he has a direct financial interest in promoting this theory. Specifically, the american diet is high in PUFA consumption. I should note that his paper was not a medical study, it was a hypothesis paper published in Journal of Orthomolecular Medicine. And certainly NOTHING like what they talk at the website. Furthermore, prior to publishing his hypothesis paper he applied and received a US patent for B5 acne treatment. Totally recommend it, But many have reported side effects so I would recommend starting at a Low Does with some Anti Oxidants. who knows? One of the known side-effects is diarrhea and apparently B5 has been used as constipation treatment. It is very difficult to consider it a placebo as well seeing as I for three periods eliminated it completely just to see if the acne had been cured but within 1-2 weeks it all went downhill from there until I started with B5 again (about 6000 mg/day). It seemed fairly rigorous and am inclined to believe the results. That’s why you keep writing articles. I also think you seem to be more concerned with making money by selling books than you are with actually helping anyone. This observation forms the basis of my hypothesis that the disease process may be connected with fat metabolism– or a deficiency of it. Vitamin B5 (pantothenic acid) is a component of Coenzyme A. Coenzyme A is necessary for hormone production as well as fatty acid metabolism. Everything You Need to Know About Vitamin B5 for Acne. Well, the AcneEase study is as bad as they come – and then some. Exogenous (externally derived) androgens do cause acne. This is not a joke – and several people at our church now take it for their kids acne and have had great results. Other regulatory agencies pretty much say the same thing. He has a very strong reason to believe his theory is correct. For me it worked. I haven’t read it in detail yet, but from what I remember the paper mentioned something about B5 supplementation increasing skin moisture and softness. 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